After naloxone administration, what should you monitor for?

• A. Return of reverse sedation, potential re-narcotization with longer-acting opioids, and improvement in respirations; monitor vitals
• B. Increase in blood pressure alone
• C. Onset of hyperglycemia
• D. No monitoring is necessary

Answer: (A)

Naloxone reverses opioid effects but wears off sooner than many opioids, so continuous monitoring for respiratory status and potential re-narcotization is essential. After administration, watch for the return of sedation or decreased consciousness and for renewed respiratory depression as the antagonist’s effect fades. Keep a close eye on respirations, oxygen saturation, airway status, and vital signs, and be prepared to repeat naloxone or provide airway support if needed. This approach makes sense because the patient can deteriorate again if a longer-acting opioid is involved or if the naloxone dose wears off. Monitoring only blood pressure misses the crucial aspect of breathing and airway; hyperglycemia isn’t expected in this setting; and skipping monitoring risks unrecognized respiratory compromise.